Tumor biology

Genetic and molecular aspects related to neoplastic transformation. Cell

changes ascribed to particular stages of the carcinogenesis. Cells of the immune system and

soluble mediators associated with neoplastic growth. Tumor differentiation based on cell

morphology as well as variability of TSA and TAA markers. Molecular properties related to the

malignancy of tumors in selected examples. Cell pathways related to the growth, survival and

mobility of transformed cells. Molecular and cellular basis of EMT and MET processes. Cellular and

receptor changes related to neoplastic metastasis. The mechanism of the spread of neoplastic

cells depending on the migration route. Cellular and molecular aspects of targeted migration of

neoplastic cells to specific organs. Targeted, molecular and genetic methods of diagnosis and

treatment of cancer patients.

Molls M., Vaupel P., Nieder C., Anscher M.S. eds The impact of tumor

biology on cancer treatment and multidisciplinary strategies. 2009, Springer - Verlag Heidelberg.

Based on Appendix 5 to Senate Resolution No XXIV-27.18/19

W1 - Student knows and understand basic facts concerning tumor development and direct relationships with other scientific disciplines.

W2 - Student knows the specific methods used to detect tumor and understand the backgrounds of their applications.

U1 - Student is able on the basis of received knowledge to resolve simple problems concernig tumor development and possibilities of is detection and combat.

U2- Student is able to find out on the basis of they knowledge to combine facts and resolve problems linked with molecular procesess of tumor growth.

U5 - Student is able to use specialized terminology during discussions covering oncological issues.

K1 - Student .respects the importance of research in the field of preliminary and clinical oncology

K3 - Student is able to present the acquired knowledge in the field of tumor biology to a wide audience